GABAergic Excitation of Vasopressin Neurons
نویسندگان
چکیده
منابع مشابه
GABAergic excitation of vasopressin neurons: possible mechanism underlying sodium-dependent hypertension.
RATIONALE Increased arginine-vasopressin (AVP) secretion is a key physiological response to hyperosmotic stress and may be part of the mechanism by which high-salt diets induce or exacerbate hypertension. OBJECTIVE Using deoxycorticosterone acetate-salt hypertension model rats, we sought to test the hypothesis that changes in GABA(A) receptor-mediated inhibition in AVP-secreting magnocellular...
متن کاملGABAergic Excitation of Vasopressin Neurons: A Possible Mechanism Underlying Sodium-Dependent Hypertension
Department of Physiology, Korea University College of Medicine, Seoul 136-705, Republic of Korea; Neuroscience Research Institute, Korea University College of Medicine; Department of Physiology, Biomedical Science Institute and Brain Korea 21 Project Center, Kyung Hee University School of Medicine, Seoul 130-701, Republic of Korea, and; Department of Psychiatry & Biobehavioral Sciences, Univers...
متن کاملChronic hyperosmotic stress converts GABAergic inhibition into excitation in vasopressin and oxytocin neurons in the rat.
In mammals, the increased secretion of arginine-vasopressin (AVP) (antidiuretic hormone) and oxytocin (natriuretic hormone) is a key physiological response to hyperosmotic stress. In this study, we examined whether chronic hyperosmotic stress weakens GABA(A) receptor-mediated synaptic inhibition in rat hypothalamic magnocellular neurosecretory cells (MNCs) secreting these hormones. Gramicidin-p...
متن کاملVasopressin increases GABAergic inhibition of rat hypothalamic paraventricular nucleus neurons in vitro.
This investigation used an in vitro hypothalamic brain slice preparation and whole cell and perforated-patch recording to examine the response of magnocellular neurons in hypothalamic paraventricular nucleus (PVN) to bath applications of vasopressin (VP; 100-500 nM). In 22/38 cells, responses were characterized by an increase in the frequency of bicuculline-sensitive inhibitory postsynaptic pot...
متن کاملNO inhibits supraoptic oxytocin and vasopressin neurons via activation of GABAergic synaptic inputs.
To study modulatory actions of nitric oxide (NO) on GABAergic synaptic activity in hypothalamic magnocellular neurons in the supraoptic nucleus (SON), in vitro and in vivo electrophysiological recordings were obtained from identified oxytocin and vasopressin neurons. Whole cell patch-clamp recordings were obtained in vitro from immunochemically identified oxytocin and vasopressin neurons. GABAe...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2013
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.113.301814